藥物化學/常用縮寫
外观
< 藥物化學
數字
[编辑]- 5-HT
- 5-羥色胺(5-hydroxytryptamine),又稱血清素(serotonin)
- 7-ACA
- 7-氨基頭孢烯酸(7-aminocephalosporinic acid)
- 6-APA
- 6-氨基青黴烷酸(6-aminopenicillanic acid)
A
[编辑]- ACE
- 血管緊張素轉化酶(angiotensin-converting enzyme)
- ACh
- 乙醯膽鹼(acetylcholine)
- AChE
- 乙醯膽鹼酯酶(acetylcholinesterase)
- ACT
- 青蒿素聯合治療(artemisinin combination therapy)
- ADAPT
- 抗體導向的抗體酶(abzyme)藥物前治療(antibody-directed abzyme prodrug therapy)
- ADEPT
- 抗體導向的酶(enzyme)藥物前治療(antibody-directed enzyme prodrug therapy)
- ADH
- 醇脫氫酶(alcohol dehydrogenase)
- ADME
- 吸收,分佈,代謝,排泄(absorption, distribution, metabolism,excretion)
- ADP
- 二磷酸腺苷(adenosine diphosphate)
- AIC
- 5-氨基咪唑-4-甲酰胺(5-aminoimidazole-4-carboxamide)
- AIDS
- 後天免疫缺乏症,愛滋病(acquired immune deficiency syndrome)
- AML
- 急性骨髓性白血病(acute myeloid leukaemia)
- AMP
- 磷酸腺苷(adenosine 5'-monophosphate)
- AT
- 血管緊張素(angiotensin)
- ATP
- 三磷酸腺苷(adenosine 5'-triphosphate)
- AUC
- 曲線下方面積(area under the curve)
- cAMP
- 環磷酸腺苷(cyclic AMP)
B
[编辑]- BuChE
- 丁酰膽鹼酯酶(butylcholinesterase)
C
[编辑]- CCK
- 膽囊收縮素(cholecystokinin)
- CDKs
- 細胞週期蛋白依賴性激酶(cyclin-dependent kinases)
- CETP
- 膽固醇酯轉移蛋白(cholesteryl ester transfer protein)
- cGMP
- 環磷酸鳥苷(cyclic GMP)
- CHO cells
- 中國倉鼠卵巢細胞(Chinese hamster ovarian cells)
- CKIs
- 細胞週期蛋白依賴性激酶抑制劑(cyclin-dependent kinase inhibitors)
- CLogP
- 分配係數的計算對數(calculated logarithm of the partition coefficient)
- CML
- 慢性骨髓性白血病(chronic myeloid leukaemia)
- CMV
- 巨細胞病毒(cytomegalovirus)
- CNS
- 中央神經系統(central nervous system)
- CoA
- 輔酶A(coenzyme A)
- CoMFA
- 比較分子場分析(comparative molecular field analysis)
- COMT
- 兒茶酚O-甲基轉移酶(catechol O -methyltransferase)
- COX
- 環氧合酶(cyclooxygenase)
- CSD
- 劍橋結構數據庫(Cambridge Structural Database)
- CYP
- 構成細胞色素P450家族的酶
D
[编辑]- D-Receptor
- 多巴胺受體(dopamine receptor)
- dATP
- 脫氧腺苷三磷酸(deoxyadenosine triphosphate)
- DCC
- 二環己基碳二亞胺(dicyclohexylcarbodiimide)
- dCTP
- 脫氧胞嘧啶三磷酸(Deoxycytosine triphosphate)
- DG
- 二酰基甘油(diacylglycerol)
- dGTP
- 去氧鳥苷三磷酸(deoxyguanosine triphosphate)
- DHFR
- 二氫葉酸還原酶(dihydrofolate reductase)
- DMAP
- 二甲基氨基吡啶(dimethylaminopyridine)
- DNA
- 去氧核糖核酸(deoxyribonucleic acid)
- DOR
- δ阿片受體(delta opioid receptor)
- dsDNA
- 雙鏈DNA(double-stranded DNA)
- dsRNA
- 雙鏈RNA(double-stranded RNA)
- dTMP
- 脫氧胸苷酸單磷酸(deoxythymidylate monophosphate)
- dTTP
- 脫氧胸苷酸三磷酸酯(deoxythymidylate triphosphate)
- dUMP
- 脫氧尿苷酸單磷酸(deoxyuridylate monophosphate)
E
[编辑]- EC50
- 達到最大可能效力的50%,所需要的藥物濃度
- Es
- Taft's 空間因子(Taft's steric factor)
- EGF
- 表皮生長因子(epidermal growth factor)
- EGF-R
- 表皮生長因子受體(epidermal growth factor receptor)
- EMEA
- 歐洲藥品評估機構(European Agency for the Evaluation of Medicinal Products)
- EPC
- 歐洲專利公約(European Patent Convention)
- EPO
- 歐洲專利局(European Patent Office)
F
[编辑]- FDA
- 美國食品和藥物管理局(US Food and Drug Administration)
- FdUMP
- 氟脫氧尿嘧啶單磷酸酯(fluoro deoxy uracil monophosphate)
- FGF
- 成纖維細胞生長因子(fibroblast growth factor)
- FGF-R
- 成纖維細胞生長因子受體(fibroblast growth factor receptor)
- FH4
- 四氫葉酸(tetrahydrofolate)
- F
- 口服生物利用度(oral bioavailability)
- F
- 芳香族取代基在QSAR中的誘導作用(inductive effect of an aromatic substituent in QSAR)
- F-SPE
- 氟固相萃取(fluorous solid phase extraction)
- FLOG
- flexible ligands oriented on grid
- FPGS
- 葉酰聚谷氨酸合成酶(folylpolyglutamate synthetase)
- FPP
- 法呢基二磷酸酯(farnesyl diphosphate)
- FT
- 法呢基轉移酶(farnesyl transferase)
- FTI
- 法呢基轉移酶抑制劑(farnesyl transferase inhibitor)
G
[编辑]- G-Protein
- 鳥嘌呤核苷酸結合蛋白(guanine nucleotide binding protein)
- GABA
- γ-氨基丁酸(γ-aminobutyric acid)
- GAP
- GTP酶激活蛋白(GTPase activating protein)
- GCP
- 藥品優良臨床試驗規範(Good Clinical Practice)
- GDEPT
- 基因定向酶前藥治療(gene-directed enzyme prodrug therapy)
- GDP
- 鳥苷二磷酸(guanosine diphosphate)
- GEF
- 鳥嘌呤核苷酸交換因子(guanine nucleotide exchange factors)
- GGTase
- 香葉基香葉基轉移酶(geranylgeranyltransferase)
- GH
- 生長激素(growth hormone)
- GIT
- 胃腸道(gastrointestinal tract)
- GLP
- 優良實驗室操作(Good Laboratory Practice)
- GMC
- 綜合醫務委員會(General Medical Council)
- GMP
- 良好生產規範(Good Manufacturing Practice)
- GMP
- 鳥苷酸單磷酸(guanosine monophosphate)
- GnRH
- 促性腺激素釋放激素(gonadotropin-releasing hormone)
- gp
- 糖蛋白(glycoprotein)
- GSK
- 葛蘭素史克公司(GlaxoSmithKline)
- GTP
- 鳥苷三磷酸(guanosine triphosphate)
H
[编辑]- h-PEPT
- 人腸道質子依賴寡肽轉運蛋白(human intestinal proton-dependent oligopeptide transporter)
- H-receptor
- 組織胺受體(histamine receptor)
- HA
- 血凝素(hemagglutinin)
- HAART
- highly active antiretroviral therapy
- HAMA
- 人抗小鼠抗體(human anti-mouse antibodies)
- HBA
- 氫鍵受體(hydrogen bond acceptor)
- HBD
- 氫鍵供體(hydrogen bond donor)
- HCV
- C型肝炎病毒(hepatitis C virus)
- HDL
- 高密度脂蛋白(high density lipoprotein)
- HERG
- 人類醚轉運相關基因(human ether-a-go-go related gene)
- HIF
- 缺氧誘導因子(hypoxia-inducible factor)
- HIV
- 人類免疫缺陷病毒(human immunodefi ciency virus)
- HMGSCoA
- 3-羥基-3-甲基戊二酰輔酶A(3-hydroxy-3-methylglutaryl-coenzyme A)
- HMGR
- 3-羥基-3-甲基戊二酰輔酶A還原酶(3-hydroxy-3-methylglutaryl-coenzyme A reductase)
- HOMO
- 最高佔有分子軌道(highest occupied molecular orbital)
- HPLC
- 高效液相色譜(high-performance liquid chromatography)
- HPMA
- N-(2-羥丙基)甲基丙烯酰胺(N-(2-hydroxypropyl)methacrylamide)
- HPT
- 人腸道二肽/三肽轉運蛋白(human intestinal di-/tri peptide transporter)
- HRV
- 人類鼻病毒(human rhinoviruses)
- HSV
- 單純皰疹病毒(herpes simplex virus)
- HTS
- 高通量篩選(high-throughput screening)
I
[编辑]- IC50
- 將標靶抑制50%所需的藥物濃度
- IGF-1R
- 胰島素生長因子1受體(insulin growth factor 1 receptor)
- IND
- 新藥研究豁免(Investigational Exemption to a New Drug Application)
- IP3
- 肌醇三磷酸(inositol triphosphate)
- IPER
- 國際初步審查報告(International Preliminary Examination Report)
- IRB
- 機構審查委員會(Institutional Review Board)
- ISR
- 國際搜索報告(International Search Report)
- ITC
- 等溫滴定量熱法(isothermal titration calorimetry)
- IUPAC
- 國際純化學和應用化學聯合會(International Union of Pure and Applied Chemistry)
- IV
- 靜脈(intravenous)
K
[编辑]- KD
- 解離結合常數(dissociation binding constant)
- Ki
- 抑制常數(inhibition constant)
- KM
- 米氏常數(Michaelis constant)
- KOR
- κ-阿片受體(kappa opioid receptor)
L
[编辑]- LAAM
- L-α-乙酰甲羥(L-α-acetylmethadol)
- LD50
- 殺死50%的測試動物,所需的致死劑量
- LDH
- 乳酸脫氫酶(lactate dehydrogenase)
- LH
- 黃體激素(luteinizing hormone)
- LHRH
- 黃體激素釋放激素(luteinizing hormone-releasing hormones)
- LipE
- 親脂效率(lipophilic efficiency)
- LogP
- 分配係數(partition coefficient)的對數
- LDL
- 低密度脂蛋白(low density lipoprotein)
- LUMO
- 最低未佔用的分子軌道(lowest unoccupied molecular orbital)
M
[编辑]- M-receptor
- 毒蕈鹼受體(muscarinic receptor)
- MAA
- 營銷授權申請(Marketing Authorization Application)
- MAB
- 單株抗體(monoclonal antibody)
- MAO
- 單胺氧化酶(monoamine oxidase)
- MAOI
- 單胺氧化酶抑制劑(monoamine oxidase inhibitor)
- MAOS
- 微波輔助有機合成(microwave assisted organic synthesis)
- MAP
- 絲裂原活化蛋白(mitogen-activated protein)
- MAPK
- 絲裂原活化蛋白激酶(mitogen-activated protein kinases)
- MCH-R
- 黑色素濃縮激素受體(melanin-concentrating hormone receptor)
- MDR
- 多重抗藥性(multidrug resistance)
- MDRTB
- 多重抗藥性結核病(multidrug-resistant tuberculosis)
- MEP
- 分子靜電勢(molecular electrostatic potential)
- miRNA
- 微RNA(micro RNA)
- miRNP
- 微RNA蛋白(micro RNA protein)
- MMP
- 基質金屬蛋白酶(matrix metalloproteinase)
- MMPI
- 基質金屬蛋白酶抑制劑(matrix metalloproteinase inhibitor)
- MOR
- μ-阿片受體(mu opioid receptor)
- MR
- 摩爾折射率(molar refractivity)
- mRNA
- 信使RNA(messenger RNA)
- MRSA
- 抗甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus)
- MTDD
- 多目標新藥研發(multi-target drug discovery)
- mTRKI
- 多酪氨酸受體激酶抑制劑(multi-tyrosine receptor kinase inhibitor)
- MWt
- 分子量(molecular weight)
N
[编辑]- N-receptor
- 菸鹼受體(nicotinic receptor)
- NA
- 神經氨酸酶(neuraminidase)或去甲腎上腺素(noradrenaline)
- NAD+ /NADH
- 煙酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide)
- NADP+ /NADPH
- 煙酰胺腺嘌呤二核苷酸磷酸(nicotinamide adenine dinucleotide phosphate)
- NAG
- N-乙酰氨基葡萄糖(N-acetylglucosamine)
- NAM
- N-乙酰谷氨酸(N-acetylmuramic acid)
- NCE
- 新化學實體(new chemical entity)
- NDA
- 新藥申請(New Drug Application)
- NICE
- 國家健康與臨床優化研究所(National Institute for Health and Clinical Excellence)
- NMDA
- N-甲基-D-天冬氨酸(N -methyl-D-aspartate)
- NME
- 新分子實體(new molecular entity)
- NMR
- 核磁共振(nuclear magnetic resonance)
- NNRTI
- 非核苷逆轉錄酶抑制劑(non-nucleoside reverse transcriptase inhibitor)
- NO
- 一氧化氮(nitric oxide)
- NOR
- 痛敏肽阿片受體(nociceptin opioid receptor)
- NOS
- 一氧化氮合酶(nitric oxide synthase)
- NRTI
- 核苷逆轉錄酶抑制劑(nucleoside reverse transcriptase inhibitor)
- NSAID
- 非類固醇消炎藥(non-steroidal anti-inflammatory drug)
- NVOC
- 硝基甲酰氧基羰基(nitroveratryloxycarbonyl)
O
[编辑]- ORL1
- 阿片受體樣受體(opioid receptor-like receptor)
P
[编辑]- P
- 分配係數(partition coefficient)
- PABA
- 對氨基苯甲酸(p-aminobenzoic acid)
- PBP
- 青黴素結合蛋白(penicillin binding protein)
- PCP
- 苯環利定(phencyclidine),別名「天使塵」(angel dust)
- PCT
- 專利合作條約(patent cooperation treaty)
- PDB
- 蛋白質數據庫(protein data bank)
- PDE
- 磷酸二酯酶(phosphodiesterase)
- PDGF
- 血小板衍生生長因子(platelet-derived growth factor)
- PDGF-R
- 血小板衍生生長因子受體(platelet-derived growth factor receptor)
- PDT
- 光動力療法(photodynamic therapy)
- PEG
- 聚乙二醇(polyethylene glycol)
- PGE
- 前列腺素E(prostaglandin E)
- PGF
- 前列腺素F(prostaglandin F)
- PIP2
- 磷脂酰肌醇二磷酸(phosphatidylinositol diphosphate)
- PI
- 蛋白酶抑制劑(protease inhibitor)
- PKA
- 蛋白激酶A(protein kinase A)
- PKB
- 蛋白激酶B(protein kinase B)
- PKC
- 蛋白激酶C(protein kinase C)
- PLC
- 磷脂酶C(phospholipase C)
- PLS
- 偏最小平方法(partial least squares)
- PPBI
- 蛋白質 - 蛋白質結合抑制劑(protein–protein binding inhibitor)
- PPI
- 質子幫浦抑制劑(proton pump inhibitor)
- PPts
- 吡啶鎓4-甲苯磺酸鹽(pyridinium 4-toluenesulfonate)
Q
[编辑]- QSAR
- 定量結構活性關係(quantitative structure–activity relationships)
R
[编辑]- r
- 回歸或相關係數(regression or correlation coefficient)
- R
- 芳香族取代基在QSAR中的共振效應(resonance effect of an aromatic substituent in QSAR)
- RES
- 網狀內皮系統(reticuloendothelial system)
- RFC
- 還原葉酸載體(reduced folate carrier)
- RISC
- RNA誘導沉默複合物(RNA induced silencing complex)
- RMSD
- 均方根距離(root mean square distance)
- rRNA
- 核醣體RNA(ribosomal RNA)
- RNA
- 核糖核酸(ribonucleic acid)
S
[编辑]- s
- 估計或標準偏差的標準差(standard error of estimate or standard deviation)
- SAR
- 結構活性關係(structure–activity relationships)
- SCAL
- 安全捕獲酸不穩定接頭(safety-catch acid-labile linker)
- SCF
- 幹細胞因子(stem cell factor)
- SCID
- 嚴重複合型免疫缺乏症(severe combined immunodeficiency disease)
- SKF
- 史密斯-葛蘭-佛蘭西公司(Smith-Kline and French),葛蘭素史克公司(GlaxoSmithKline,GSK)的前身
- SNRI
- 選擇性去甲腎上腺素再攝取抑制劑(selective noradrenaline reuptake inhibitors)
- siRNA
- 小抑制性RNA(small inhibitory RNA)
- snRNA
- 小核RNA(small nuclear RNA)
- SOP
- 標準操作流程(standard operating procedure)
- SPA
- 鄰近閃爍分析技術(scintillation proximity assay)
- SPE
- 固相萃取(solid phase extraction)
- SPOS
- 溶液相有機合成(solution phase organic synthesis)
- SPR
- 表面等離子體共振(surface plasmon resonance)
- ssDNA
- 單鏈DNA(single-stranded DNA)
- SSRI
- 選擇性血清素再攝取抑制劑(selective serotonin reuptake inhibitor)
- ssRNA
- 單鏈RNA(single-stranded RNA)
T
[编辑]- TB
- 肺結核(tuberculosis)
- TCA
- 三環抗抑鬱藥(tricyclic antidepressants)
- TFA
- 三氟乙酸(trifluoroacetic acid)
- TGF-α
- 轉化生長因子-α(transforming growth factor-α)
- TGF-β
- 轉化生長因子-β(transforming growth factor-β)
- THF
- 四氫呋喃(tetrahydrofuran)
- TM
- 跨膜(transmembrane)
- TNF
- 腫瘤壞死因子(tumour necrosis factor)
- TNF-R
- 腫瘤壞死因子受體(tumour necrosis factor receptor)
- TNT
- 三硝基甲苯(trinitrotoluene)
- TRAIL
- TNF相關凋亡誘導配體(TNF-related apoptosis-inducing ligand)
- TRIPS
- 貿易相關方面的知識產權(trade related aspects of intellectual property rights)
- tRNA
- 轉移RNA(transfer RNA)
U
[编辑]- UTI
- 尿道感染(urinary tract infection)
V
[编辑]- vdW
- 凡德華(van der Waals)
- VEGF
- 血管內皮生長因子(vascular endothelial growth factor)
- VEGF-R
- 血管內皮生長因子受體(vascular endothelial growth factor receptor)
- VIP
- 血管活性腸肽(vasoactive intestinal peptide)
- VOC–Cl
- 乙烯基氧羰基氯(vinyloxycarbonyl chloride)
- VRE
- 抗萬古黴素腸球菌(vancomycin-resistant enterococci)
- VRSA
- 抗萬古黴素金黃色葡萄球菌(vancomycin-resistant Staphylococci aureus)
- VZV
- 水痘帶狀皰疹病毒(varicella-zoster viruses)
W
[编辑]- WHO
- 世界衛生組織
- WTO
- 世界貿易組織